The dosage should be adjusted for the individual case based on the response of the patient and laboratory investigations, and should be administered daily. Pharmacokinetic trials demonstrate that once daily dosing gives higher blood levels than dividing the daily dose over the day.

The commonly prescribed dose is 22 µg/kg bodyweight/day. This is frequently too low, and doses of up to 44 µg/kg bodyweight/day may be required.

Appropriate laboratory tests should be conducted to confirm the diagnosis and ensure correct dosage. For oral administration.