For oral administration to dogs.

Follow the dosage instructions given by your veterinary surgeon. In clinical studies, an average starting dose of 6 mg/kg once daily was effective; however, the dose should be adjusted according to individual response, as determined by monitoring by your veterinary surgeon. Most dogs were eventually stabilised on doses between 2-10 mg/kg/day. Administer orally, once daily, with food. Dosing in the morning is preferable as this will allow your veterinary surgeon to perform monitoring tests 4-6 hours following administration of the dose.

Do not divide or open capsules.

Amounts to be administered: Practical starting doses are recommended as follows:

The dose should then be titrated according to individual response as determined by monitoring.

Should symptoms not be adequately controlled for an entire 24 hour inter-dose period, consideration should be given to increasing the daily dose by as small an increment as possible and dividing it between morning and evening doses. A small number of animals may require doses significantly in excess of 10 mg per kg bodyweight per day. In these situations appropriate additional monitoring should be implemented.

10 mg capsules should be used in dogs that require particularly small doses of Trilostane, and to assist with dosage adjustments.

Where there is no apparent response to treatment, the diagnosis should be re-evaluated. Dose increases may be necessary. Do not use in dogs weighing less than 3 kg.

Monitoring: Samples should be taken for biochemistry (including electrolytes) and an ACTH stimulation test pre-treatment and then at 10 days, 4 weeks, 12 weeks, and thereafter every 3 months, following initial diagnosis and after each dose adjustment. It is imperative that ACTH stimulation tests are performed 4-6 hours post-dosing to enable accurate interpretation of results.

Regular assessment of the clinical progress of the disease should also be made at each of the above time points.