For the prevention and treatment of bovine pneumonia associated with bovine respiratory Mycoplasma or Pasteurella multocida sensitive to tylosin.

For the control of Mycoplasma synoviae airsacculitis in chickens and Mycoplasma gallisepticum S6 in chickens and turkeys. In the field Tylan Soluble has also proved useful in reducing the level of infection following stress association with live vaccination.

For the prevention and control of enzootic pneumonia, swine dysentery and other scours caused by organisms (e.g. Lawsonia intracellularis) sensitive to tylosin, in pigs.

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridia perfringens in chickens.