Introduction

vet01601

Company name: Elanco Animal Health

Address: Eli Lilly and Company Limited

Lilly House

Priestley Road, Basingstoke

Hampshire, RG24 9NL

Telephone: 01256 353131

Fax: 01256 779510

Email: elanco.uk.info@lilly.com

Website: www.elanco.com

Presentation

Tylan Soluble is tylosin tartrate BP (Vet), a white to buff coloured soluble powder for oral solution. Each bottle contains 100 g of tylosin activity.

Uses

For the prevention and treatment of bovine pneumonia associated with bovine respiratory Mycoplasma or Pasteurella multocida sensitive to tylosin.

For the control of Mycoplasma synoviae airsacculitis in chickens and Mycoplasma gallisepticum S6 in chickens and turkeys. In the field Tylan Soluble has also proved useful in reducing the level of infection following stress association with live vaccination.

For the prevention and control of enzootic pneumonia, swine dysentery and other scours caused by organisms (e.g. Lawsonia intracellularis) sensitive to tylosin, in pigs.

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridia perfringens in chickens.

Dosage and administration

Calves

One gram of Tylan Soluble per young calf administered orally twice daily for seven to fourteen days. The product may be incorporated into the milk or reconstituted milk replacer at the time of feeding.

Chickens and turkeys

TYLAN Soluble is administered in the drinking water at a concentration of 0.5 g per litre to provide 50-200 mg/kg bw, depending on the age and the water consumption of the birds.

For routine preventative medication in poultry, the following programmes are recommended:

As an aid to mycoplasmosis prevention in chickens (refer to Table 1):

Tylan Soluble: Table 1
Class of Stock	Age	Tylan Soluble at 0.5g per litre
Broiler	0-3 days	35 g per 1000 birds
	4th week of life	35 g per 1000 birds
Layers & Replacement pullets	0-3 days	35 g per 1000 birds
	4th week of life	35 g per 1000 birds
	9th-12 th week	48 hours medication
	16th-20th week	48 hours medication
Breeders	0-3 days	50 g per 1000 birds
	4th week of life	80 g per 1000 birds
	9th, 12th, 16th, 20th, 24th weeks of age	48 hours medication

As an aid to mycoplasmosis prevention in turkeys (refer to Table 2):

Tylan Soluble: Table 2
Class of Stock	Age	Tylan Soluble at 0.5g per litre
Table Turkeys	0-5 days	12.5 g per 100 birds
	4th week of life	7.5 g per 100 birds

For treatment of mycoplasmosis (refer to Table 3):

Tylan Soluble: Table 3
Class of Stock	Tylan Soluble at 0.5g per litre
Broilers	24-72 hours medication
Layers & Replacement pullets	48-72 hours medication
Turkeys	48-120 hours medication

As an aid in the control of necrotic enteritis in chickens (refer to Table 4):

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridium perfringens in chickens use Tylan in the drinking water for 5 days at a concentration of 0.15 g per litre water (150ppm), to provide 20-50 mg/kg bw, depending on the age and the water consumption of the birds.

Tylan Soluble: Table 4
Class of Stock	Tylan Soluble at 0.15g per litre
Broilers	5 days
Layers & Replacement pullets	5 days

Pigs

For the prevention and control of swine dysentery and enzootic pneumonia, Tylan soluble is administered in the drinking water to provide 25 mg/kg bodyweight. This may be achieved by adding 0.25g per litre (1.1 g/gal).

For the prevention and control of Ileitis, Tylan soluble is administered in the drinking water to provide 5 - 10 mg/kg bodyweight. This may be achieved by adding 0.05 - 0.1g per litre (0.22 - 0.44 g/gal)

A medicated solution of drinking water should be administered until 24 hours after scouring has ceased. The diagnosis should be reviewed if no response after 5 days of medication.

Contra-indications, warnings, etc

Keep out of reach of children.

For animal treatment only.

Do not use the same solution for more than three days.

Do not leave or dispose of water containing tylosin tartrate where it may be accessible to animals not under treatment, or wildlife.

Withdrawal Period

(Refer to Table 5)

Tylan Soluble Withdrawal Periods: Table 5
				Withdrawal Period (days)
Species	Indications	Treatment Duration	Dose	Meat	Eggs
Chickens	For the control of chronic respiratory disease	5	500 mg/litre water (50-200 mg tylosin/kg bw)	1	0
Chickens	As an aid in the control of outbreaks of necrotic enteritis caused by Costridium perfringens	5	150 mg/litre water (20-50 mg tylosin/kg bw)	0	0
Turkeys	For the control of chronic respiratory disease	5	500 mg/litre water	0	n/a
Pigs	For the prevention and control of enzootic pneumonia, swine dysentery and other scours caused by organisms (eg Lawsonia intracellularis) sensitive to tylosin	3-10	250 mg/litre water (25 mg tylosin/kg bw)	0	n/a
Calves	For the control of pneumonia associated with mycoplasmata and Pasteurella multocida sensitive to tylosin.	7-14	1000 mg per calf twice daily	14	n/a

Operator warnings

Direct contact of tylosin tartrate with skin or conjuctivae should be avoided. Wash hands and any splashes immediately with soap and water.

Pharmaceutical precautions

Store in a dry place below 25°C.

Any medicated water which is not consumed within three days should be discarded.

Legal category

POM-V

Marketing authorisation number

Vm 00006/4091.