Dopram-V Solution for Injection is presented in multi-dose vials containing 20 ml of sterile solution for parenteral and topical sublingual use. Each ml contains Doxapram Hydrochloride 20 mg. It also contains Chlorbutanol 5 mg/ml as an antimicrobial preservative. Dopram-V (doxapram hydrochloride) is a potent respiratory stimulant. It differs from the analeptic agents in having greater specificity of action on the respiratory centre.

Metabolism:

The metabolism of doxapram has been studied in the dog and man. Doxapram is extensively metabolised; the metabolites and unchanged doxapram are excreted in the bile and urine. The pharmacokinetic properties of doxapram can be described by a multi-compartmental model. Due to rapid redistribution the pharmacological effects of an intravenous injection of doxapram are terminated within 15-20 minutes following administration.