For calves, the daily dose is one bolus per 40 kg (90 lb) bodyweight given orally, providing 30 mg of combined active ingredients per kg bodyweight daily.

Treatment should be repeated daily until two days after symptoms have resolved, but in cases of salmonellosis and bacterial pneumonia treatment should be continued for five consecutive days. Treatment must not continue for more than five days. Duphatrim Boluses may be administered whole, by hand or balling gun, or dispersed in water.

Dosage by dispersion in water: Disperse each bolus by shaking in about 300 ml of water in a dosing bottle. This may be facilitated by crushing the bolus before placing it in the bottle. After dosing by this method any unused material should be discarded.