For cattle and pigs the dose is 1 ml per 16 kg (35 lb) bodyweight by intramuscular or slow intravenous injection (equivalent to 15 mg of combined active ingredients per kg bodyweight) once, but in severe infections it may be repeated daily until 2 days after symptoms resolve up to a maximum of 5 days.

Duphatrim IS may be administered by intravenous injection when rapid blood levels of sulfadiazine and trimethoprim are required.

For horses the dose is 1 ml per 16 kg bodyweight daily, by slow intravenous injection only.

For dogs and cats the dose is 1 ml per 8 kg bodyweight daily, by subcutaneous injection only (equivalent to 30 mg of combined active ingredients per kg bodyweight). The recommended site in dogs is the loose skin at the base of the neck.

A single injection may be sufficient in uncomplicated conditions, but in severe infections the dose may be repeated for up to a maximum of 5 consecutive days, or until 2 days after the symptoms resolve.