Duramune® DAPPi + L is a combination vaccine comprising: one vial of a freeze dried fraction containing live attenuated strains of canine distemper virus, strain Onderstepoort, (102.5 to 104.8 TCID50); canine adenovirus, type 2, strain V197 (104.8 to 107.0 TCID50); canine parainfluenza virus, strain FDL (104.6 to 107.4 TCID50); canine parvovirus, strain SAH (104.7 to 106.5 TCID50) grown on tissue culture.

One vial of liquid diluent fraction, an inactivated suspension of Leptospira canicola outer membrane coat protein (potency as per Ph.Eur) and Leptospira icterohaemorrhagiae outer membrane coat protein (potency as per Ph.Eur). Adjuvants: Ethylene/Maleic anhydride (EMA) 0.01 ml and Neocryl XK-62 0.03 ml.