UK authorised veterinary medicinal product. Where appropriate Equimidine may be used with local anaesthetics. Induction of anaesthesia with Equimidine and ketamine may delay the effects of maintenance with halothane and special care must be taken to avoid overdosage. When Equimidine is used as premedication prior to general anaesthesia its use may delay the onset of induction. In cases of suspected overdose or if the effects of detomidine become life threatening, an alpha-2 antagonist (atipamezole) is recommended at 5-10 x the dose of detomidine in mcg/kg. A/V blocks may be prevented by I/V administration of atropine at 0.02mg/kg.