Vaccine should be used only as a tool for disease control together with environmental management and medication practices designed to minimise the incidence of disease caused by Mycoplasma Hyopneumoniae.

In any animal population there will be a small number of individuals which fail to respond fully to vaccination. Successful vaccination depends upon correct storage and administration of the vaccine and the animal's ability to respond. Immune competence can be influenced by genetic factors, intercurrent infection, age, nutritional status, concurrent drug therapy, stress, etc.

Maternally derived antibody (MDA) can interfere with the development of active immunity. Where it is likely that recent field infection or vaccination of the dam has stimulated a high antibody titre and consequently a high level of MDA, the timing of the vaccination programme should be planned accordingly.

Immunocompetence in the pig increases with age. Age at vaccination should be determined by consideration of the timing of field challenge. For example, earlier vaccination is recommended where early challenge is expected.

Evidence has been obtained from field trials that the vaccine has a protective effect up until slaughter at 30 weeks of age, when piglets in infected herds are vaccinated as recommended.

Selection of herds where vaccine use is appropriate and continued monitoring should be carried out by the supervising veterinary surgeon.

It is good practice to allow vaccine to warm to body temperature in the hand or pocket before administration, to avoid the discomfort of injections of a cold liquid.