Introduction

FDAH

Address: Flanders Road

Hedge End

Southampton SO30 4QH

Telephone: 01489 781711

Fax: 01489 788306

Presentation

Duphamox Palatable Tablets 40 mg are presented as off-white circular tablets scored on one face. Each tablet contains 40 mg amoxicillin as Amoxicillin Trihydrate BP in a highly palatable base.

Chemically, amoxicillin is 6-[D(-)-α-amino-p- hydroxyphenylacetamido] penicillanic acid.

Uses

Duphamox Palatable Tablets 40 mg are indicated for use only in cats and dogs for the treatment of infections of the alimentary tract, respiratory tract and urogenital tract, eye, ear, skin and wound infections caused by susceptible organisms.

Duphamox is a broad-spectrum semi-synthetic penicillin, bactericidal in action. In vitro activity has been demonstrated against a wide range of Gram-positive and Gram-negative bacteria found in cats and dogs which include: Bacillus cereus, Bordetella bronchiseptica, Corynebacterium spp, Citrobacter freundii, Chromobacter spp, Escherichia coli, Flavobacter spp, Proteus mirabilis, Pasteurella spp, including P. multocida, Salmonella spp, Staphylococci (penicillin-sensitive strains) and Streptococci.

Dosage and administration

To be administered orally at a dose rate of 10 mg/kg bodyweight twice daily for seven days. Tablets are given orally by hand or crushed in food. The following is intended as a guide:

Cats 1 × 40 mg tablet per 4 kg bodyweight twice daily for 7 days.

Dogs 2 × 40 mg tablets per 8 kg bodyweight twice daily for 7 days.

As high blood levels are achieved rapidly after oral dosing parenteral antibiotic treatment may not be necessary.

Duphamox Palatable Tablets 40mg are normally accepted from the hand. However for the treatment of fastidious animals the tablets may be crushed and added to a little food. Any remaining medicated feed should be disposed of at the end of the day.

Contra-indications, warnings, etc

FOR ANIMAL TREATMENT ONLY

In common with all penicillins, Duphamox Palatable Tablets 40 mg should not be given to penicillin-sensitive animals.

Duphamox Palatable Tablets 40 mg should not be used in rabbits, guinea pigs, gerbils and hamsters.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

2. Handle this product with great care to avoid exposure, taking all recommended precautions.

3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.

4. Wash hands after use.

Pharmaceutical precautions

Do not store above 25°C. Store in a dry place. Keep out of the reach of children.

Legal category

POM-V

Packaging Quantities

Duphamox Palatable Tablets 40 mg are supplied in plastic containers of 500 tablets.

Further information

After absorption, high levels of amoxicillin are found throughout the tissues especially in kidney, urine, liver and bile.

Amoxicillin provides rapid bactericidal action and due to its mode of action normally prevents recrudescence of sensitive respiratory infections. In common with other penicillins an absence of toxicity has been demonstrated even at very high dose levels.

Disposal:

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.