Uses

Moxidectin is a second generation macrocyclic lactone of the milbemycin family.

For the treatment and prevention of mixed infestations by the following gastro-intestinal nematodes, respiratory nematodes and certain arthropod parasites:

Adult and immature gastro-intestinal nematodes:

•Haemonchus placei

•Haemonchus contortus

•·Ostertagia ostertagi (including inhibited larvae)

•Trichostrongylus axei

•Trichostrongylus colubriformis

•Nematodirus helvetianus (adults only)

•Nematodirus spathiger

•Cooperia surnabada

•Cooperia oncophora

•Cooperia pectinata

•Cooperia punctata

•Oesophagostomum radiatum

•Bunostomum phlebotomum (adults only)

•Chabertia ovina (adults only)

•Trichuris spp. (adults only)

Adult and immature respiratory tract nematode

•Dictyocaulus viviparus

Warble grubs (migrating larvae)

•Hypoderma bovis

•Hypoderma lineatum

Lice

•Linognathus vituli

•Haematopinus eurysternus

•Solenopotes capillatus

•Bovicola bovis (aid in control)

Mange mites

•Sarcoptes scabiei

•Psoroptes ovis

•Chorioptes bovis (aid in control)

CYDECTIN 10% LA for Cattle has a persistent action and protects cattle for a certain duration against infection or re-infection with the following parasites for the period indicated:

Species	Protection period (days)
Dictyocaulus viviparus	120
Ostertagia ostertagi	120
Haemonchus placei	90
Oesophagostomum radiatum	150
Trichostrongylus axei	90
Linognathus vituli	133

Persistent efficacy periods have not been established for parasite species other than those included in the above list. Therefore re-infection of animals on the pasture contaminated by parasites other than these remains possible before the end of the 90 day minimum persistency period demonstrated for other specific species.

Dosage and administration

Dosage

Dosage is 0.5 ml/50 kg bodyweight, equivalent to 1.0 mg moxidectin/kg bodyweight, given by a single subcutaneous injection in the ear. Determine cattle weight to ensure correct dose rate is used. Do not overdose. Do not use in animals less than 100kg or more than 500 kg body weight.

Administration

The injection should be given subcutaneously in the ear, using an 18 gauge, 25–40 mm hypodermic needle. Any single dose syringe may be used with the 50 ml bottle. The 50 ml vial stoppers must not be broached more than 20 times. Use automatic syringe equipment for the 200 ml vial. The dorsal (outer) surface of the ear should first be cleansed with antiseptic and allowed to briefly air dry. The injection should be given subcutaneously in the loose skin on the dorsal (outer) surface of the ear, just distal to (ie slightly away from) the edge of the ear cartilage (see diagram). To accomplish this, feel for the edge of the ear cartilage closest to the head, on the dorsal (outer) surface of the ear. From this landmark, taking care to avoid blood vessels (artery, vein), the needle is inserted subcutaneously starting at a point approximately 3 to 3.5 cm distal (away from the head) and directed towards the base of the ear. Advance the needle to the hub, then gently aspirate (pull back the plunger of) the syringe to confirm that the needle is not in a blood vessel. Upon injection, the resulting depot of injected material should end up a slight distance away from the edge of the ear cartilage. Following administration, the needle is withdrawn from the skin as pressure is applied for several seconds with the thumb at the point of insertion.

Diagram: Ear injection procedure

Cydectin 1 (2)

The injection site is approximately 3.5 cm (1.5 inches) away from the edge of the ear cartilage.

Cydectin 2 (2)

Use one hand to grasp and steady the ear.

Inject subcutaneously using an 18 gauge x 25-40 mm needle.

Cydectin 3 (2)

Inject contents. Depot should end up slightly away from the edge of the ear cartilage.

Apply pressure at the point of the ear cartilage.

Apply pressure at the point of insertion as the needle is withdrawn from the skin to help seal the opening.

Due to the long lasting protection against Dictyocaulus viviparus and the stomach worms, Ostertagia ostertagi and Haemonchus placei, a single treatment with CYDECTIN 10% LA for Cattle at turn-out helps control parasitic bronchitis (lungworm) and parasitic gastro-enteritis throughout the grazing season by reducing the build-up of infective larvae on pasture associated with these parasites. For best results the injection should be given to each calf of target weight to be grazed together immediately prior to being turned out to pasture. Animals should be set stocked throughout the grazing season or moved to a pasture which has not been grazed by other cattle earlier in the season.

Contra-indications, warnings, etc

Withdrawal period

Meat and offal: 108 days.

Milk: Not permitted for use in lactating animals producing milk for human consumption or industrial purposes or within 80 days of expected parturition.

The withdrawal period is based solely on a single injection at the ear site of injection. Avoid direct contact with skin and eyes.

Wash hands after use.

Do not smoke, drink or eat while handling the product.

Take care to avoid self-injection.

Advice to Medical Practitioners in case of accidental self injection

Treat symptomatically.

Keep out of the reach of children.

Not to be mixed with other Veterinary Medicinal Products before administration. In order to prevent abscesses, a strict aseptic technique is recommended. CYDECTIN 10% LA for Cattle has been formulated specifically for subcutaneous injection in the dorsal surface of the ear of cattle and must not be given by any other route of administration or to any other species.

The product is effective against Hypoderma larvae at the time of treatment but its persistent activity against Hypoderma has not been evaluated. If the product is given before the end of the fly season complimentary treatment with a product effective against Hypoderma may be required.

To avoid possible secondary reactions by the death of Hypoderma larvae in the spine or the oesophagus of animals, it is recommended to administer CYDECTIN 10% LA for Cattle after the end of fly activity and before the larvae reach their resting sites. Consult your veterinary surgeon on the correct timing of this treatment.

Environmental safety

Extremely dangerous for fish and aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty container. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Pharmaceutical precautions

Do not store above 25°C.

Protect from light.

Following the first withdrawal, use within 28 days.

Legal category

POM-VPS

Packaging Quantities

50 ml and 200 ml high density polyethylene containers.

Further information

Clinical trials have shown that, after injection, no signs of pain were apparent. Immediate or delayed swelling may be found at the injection site. On rare occasions (approx 1%), these swellings may further develop into abscesses. The frequency of injection site swellings tends to be higher in the heavier animals. The side effects generally disappear, without treatment, within 14 days of administration, some may persist for up to 5 weeks in a number of animals (<5%) and in very rare occasions longer.

Signs of overdose are consistent with the mode of action of moxidectin. These signs are manifested as transient salivation, depression, drowsiness and ataxia 24 to 36 hours post-treatment. The signs usually disappear within 36 to 72 hours without treatment. At doses >3 times the recommended dose, the signs include recumbency, muscle tremor, ruminal tympany and dehydration. The signs can last for a few days to ten days. There is no specific antidote.

On rare occasions, depression and ataxia can be observed after injection. Cydectin 10% LA for Cattle has been shown to be safe for use in pregnant animals.

Immunity to nematodes depends on adequate exposure to infection. Although not normally the case, circumstances could occur in which anthelmintic control measures might increase the vulnerability of cattle to re-infection. Animals may be at risk towards the end of their first grazing season, particularly if the season is long, or in the following year if they move onto heavily contaminated pasture. In such instances, further control measures may be necessary.