Do not use in cats with haematological disorders, such as neutropenia, lymphopenia or thrombocytopenia.

Do not use in pregnant or lactating queens.

Do not use in cats with hypersensitivity to carbimazole.

Doses above 20 mg have only been trialled in a small number of cats. Adverse reactions may occur at this dose, therefore careful monitoring is recommended and the dose should be adjusted according to the risk/benefit assessment for the individual case.

Most frequent common adverse reactions include vomiting, diarrhoea, reduced appetite, as well as dermatological signs (pruritus, moist dermatitis, erythema, alopecia). These clinical signs are usually mild, adequately controlled by symptomatic therapy and do not require treatment discontinuation. Weight loss, dehydration, dyspnoea, lethargy, aggressiveness, disorientation, ataxia or pyrexia have also been reported in rare cases.

Treatment of hyperthyroidism may result in a reduction in the glomerular filtration rate. This can lead to unmasking of pre-existent renal dysfunction. Renal function should therefore be monitored (BUN and creatinine) before and during treatment, preferably at each visit of the dose adjustment and maintenance phases. The dose should be adjusted according to the risk/benefit assessment for the individual case.

Treatment of hyperthyroidism with carbimazole may also induce an elevation of liver enzymes (AP and ALT) or a worsening of pre-existing hepatic disorders. Liver enzymes should therefore be monitored before and during treatment, preferably at each visit of the dose adjustment and maintenance phases. Severe cases may require temporary or permanent treatment discontinuation. Liver enzyme elevations are usually reversible following drug discontinuation, although symptomatic therapy (nutritional and fluid support) may be required.

Transient anaemia, increase or decrease in white blood cell count, neutrophilia, thrombocytopenia, eosinophilia and/or lymphopenia may also occur. Haematology parameters should therefore be monitored on a regular basis before and during treatment, preferably at each visit of the dose adjustment phase and maintenance phase. Treatment discontinuation is not required except in case of persistent and marked disorder. In most cases, the abnormalities will resolve spontaneously within 1 month after treatment discontinuation.

In case of overdosage, adverse effects that may appear include, but are not limited to, weight loss, inappetence, vomiting and lethargy. Coat and skin abnormalities (erythema, hair loss), as well as haematological/biochemical changes (eosinophilia, lymphocytosis, neutropenia, lymphopenia, slight leucopenia, agranulocytosis, thrombocytopenia or haemolytic anaemia) may also appear. In particular, at a daily dose of 45 mg carbimazole, haematological changes (decreased red blood cell count, haemoglobin concentration and haematocrit, and increased mean corpuscular volume) have been reported in healthy cats. Hepatitis and nephritis have also been reported.

Total thyroxine concentrations (TT4) below the lower limit of the reference range may be observed during treatment although this is rarely linked to overt clinical signs. Decreasing the dose will lead to an increase in TT4. Dose adjustment should not be made based on TT4 only.

A small proportion of cats with thyroid adenoma may fail to respond or have a poor response to treatment. Thyroid carcinoma is a rare cause of hyperthyroidism in the cat and medical management alone is not recommended in such cases as it is not curative.

In the case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Wash hands with soap and water after handling litter used by treated animals. Do not eat, drink or smoke while handling the tablet or used litter.

Do not handle this product if you are allergic to hyperthyroidism inhibitors.

As carbimazole is a suspected human teratogen, women of child-bearing age should wear gloves when handling litter and/or vomit of treated cats.

Not applicable.

For animal treatment only. Keep out of the reach and sight of children.