20 mg/kg daily for 7 days preferably in divided doses every 8 or 12 hours, followed by 10 mg/kg daily for 7 days preferably in divided doses every 8 or 12 hours. Phenylbutazone 100 mg should not be administered to dogs of less than 5 kg bodyweight. Dogs weighing 5–10 kg should be given one Phenylbutazone 100 mg tablet daily for 7 days only. The 5 mg/kg dose for the second week is not appropriate as tablets should be administered whole. Where it is not possible to divide the daily dose, dogs should be monitored closely for signs of adverse reactions.

The tablets should be administered whole with or immediately after food. In older dogs suffering chronic musculo-skeletal disease the course of treatment at the lower dose may be extended but the patient must be regularly monitored for any possible adverse effects.

In the case of trauma, if symptoms persist after the initial two week course of treatment the diagnosis should be reassessed.