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Itrafungol:  Contra-indications, warnings, etc
 
 
Itrafungol
Contra-indications, warnings, etc
Contraindications
Do not administer to cats with hypersensitivity to itraconazole or one of the other ingredients. Do not administer to cats with impaired liver or kidney function. Do not use in pregnant or lactating queens.
Warnings
For animal use only. Keep out of reach of children. Wear latex gloves when handling the animal during treatment. Wash hands and exposed skin after use. In case of accidental contact with eyes, rinse thoroughly with water. In case of pain or irritation, seek medical advice. In case of accidental ingestion, rinse mouth with water.
Special Warnings
Treatment of dermatophytosis should not be limited to treatment of the infected animal(s). It should also include disinfection of the environment with appropriate fungicidal products, since M. canis spores can survive in the environment for up to 18 months. Other measures such as frequent vacuuming, disinfection of grooming equipment and removal of all potentially contaminated material that cannot be disinfected will minimize the risk of re-infection or spread of infection.
Clipping of the hair coat is considered useful because it removes infected hairs, stimulates new hair growth and hastens recovery. In cases with limited lesions, hair clipping can be limited to the lesions only, whereas in cats with generalized dermatophytosis, it is recommended to clip the entire hair coat. Care should be taken not to cause trauma to the underlying skin during hair clipping. Furthermore it is recommended that disposable gloves are worn during treatment or clipping of the affected animals. The hairs should be disposed of appropriately and all instruments, clippers etc. should be disinfected. Measures to prevent introduction of M. canis into groups of cats may include isolation of new cats, isolation of cats returning from shows or breeding, exclusion of visitors and periodic monitoring by Wood’s lamp or by culturing for M. canis.
Undesirable effects
Salivation, vomiting, diarrhoea and anorexia may occasionally occur. These effects are usually mild and transient. A transient increase in liver enzymes may occur. In very rare cases this was associated with icterus. In such cases, treatment should be interrupted.
Cats suffering from dermatophytosis, but also in poor general condition and/or suffering from additional diseases or impaired immunological response, should be monitored closely during treatment. Because of their condition, this category of animals may be more sensitive to the development of adverse effects. In case of a serious adverse effect, treatment should be interrupted and supportive care therapy (fluid therapy) should be initiated if necessary. Serum ALT and AST levels can be monitored.
In humans, itraconazole has been associated with heart failure due to a negative inotropic effect. Cats suffering form heart diseases should be carefully monitored and the treatment should be withdrawn if the clinical signs deteriorate.
Pharmaceutical precautions
Do not store above 25 °C. In-use shelf life: 5 weeks. When the container is opened for the first time, the date on which any product remaining in the container must be discarded should be calculated. This discard date should be written in the space provided on the label. After each dose, the syringe should be washed and dried and the bottle cap screwed back on tightly.
           
 
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  Date updated: 28 September 2007