Frequent and repeated use may lead to the development of resistance. It is important that the correct dose is given in order to minimise the risk of resistance. To avoid under-dosing, animals should be grouped according to their bodyweight and dosed according to the dose of the heaviest animal in the group.

Clinical symptoms of ivermectin toxicity include ataxia and depression. No antidote has been identified. In case of overdose, symptomatic treatment should be given. No signs of toxicity were observed in animals treated at up to 3 times the recommended dose rate.

Transitory discomfort has been observed in some animals immediately following subcutaneous administration. In cattle this may include jumping and rolling, but behaviour returns to normal after 15 minutes. Soft tissue swelling and thickening of the skin at the injection site has been observed in treated animals. Typically these reactions are transient and disappear within one to four weeks. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.