Introduction

Company name: Janssen Animal Health

A division of Janssen-Cilag Ltd

50-100 Holmers Farm Way

High Wycombe

Buckinghamshire

HP12 4EG

Telephone: 01494 567555

Fax: 01494 567556

Email: ahealth@jacgb.jnj.com

Presentation

White oral suspension containing 50 mg closantel per ml.

Uses

For the control of chronic and sub-acute fascioliasis (due to Fasciola hepatica) in sheep and lambs. For the control of Oestrus ovis (Sheep Nasal Bot Fly). For the control of inhibited, immature and adult stages of Haemonchus contortus (Barber Pole worm) including benzimidazole resistant strains.

Flukiver is active against mature and immature flukes.

Stage	% kill
Adults	97–100 %
6–8 weeks immature	91-95 %
5 weeks immature	91 %
3–4 weeks immature	23–73 %

Ticks (Ixodes ricinus) feeding on sheep at the time of treatment are likely to produce fewer viable eggs.

Dosage and administration

1 ml of Flukiver per 5 kg bodyweight (i.e. 10 mg closantel per kg bodyweight).

For example:
Bodyweight	Dose
Up to 5 kg	1 ml
10 kg	2 ml
20 kg	4 ml
30 kg	6 ml
40 kg	8 ml
50 kg	10 ml
60 kg	12 ml
70 kg	14 ml
80 kg	16 ml

Give orally as a drench. Suitable for use with most types of standard drenching equipment. Shake well before use.

Suggested dosing schedule

Fluke

All sheep on fluke-infested pasture should be dosed at regular intervals during the fluke season (Sept–Mar). Regional fluke forecasts from DEFRA assist in the choice of dosing time and interval.

Since closantel has been shown to delay egg-laying for up to 13 weeks after artificial infection, treatment intervals of 10–12 weeks throughout the fluke season are recommended. In severe fluke seasons, more frequent dosing may be necessary.

The treatment of ewes with a single dose of Flukiver in the spring will contribute to reducing pasture contamination during the following summer and autumn.

Any sheep brought in from liver fluke infested areas should be dosed before they join the flock.

H. contortus

For the treatment and prevention of benzimidazole resistant and susceptible H. contortus, dose at lambing to help prevent pasture contamination by infected ewes. Treat all animals at 6 weekly intervals during high risk periods in summer and autumn.

Contra-indications, warnings, etc

Flukiver must not be administered to lactating sheep producing milk for human consumption. Do not exceed the stated dose of Flukiver.

Withdrawal periods

Animals must not be slaughtered for human consumption during treatment. Sheep may be slaughtered for human consumption only after 42 days from the last treatment.

Overdose

Symptoms of acute overdosage are decreased vision or blindness, anorexia, incoordination and general weakness.

Operator warnings

Wash hands after administration.

Pharmaceutical precautions

The time between withdrawal of the first and last doses from the container should not be unduly prolonged. Do not store above 25 °C. Protect from light. For animal treatment only. Keep out of the reach of children.

Legal category

POM-VPS

Packaging Quantities

1 L, 2.5 L and 5 L plastic flexipacks.

Further information

Flukiver can be used in all age groups of sheep and lambs. It can also be used in rams at any time including during the breeding season. It can be used at any time during pregnancy.

Marketing authorisation number

Vm 00242/4023.