A combined live freeze-dried vaccine against canine distemper, infectious canine hepatitis, canine parvovirus and canine parainfluenza virus type 2. Each 1-ml dose of vaccine contains attenuated canine distemper virus, at least 104.0 CCID50, attenuated canine adenovirus (CAV2), at least 102.5 CCID50, attenuated canine parvovirus, at least 104.9 CCID50, attenuated canine parainfluenza type 2 virus, at least 104.7 CCID50