Fipronil is a member of the phenylpyrazole family of broad spectrum, non-systemic, insecticides/acaricides, which acts by blocking the GABA receptor to kill the target parasite on contact. It exhibits insecticidal and acaricidal activity against fleas (Ctenocephalides spp.), ticks (Rhipicephalus spp. and Ixodes spp.) and lice (Trichodectes spp. and Felicola spp.) in the dog and cat. FRONTLINE Spray may aid in the control of a number of ectoparasite species in dogs and cats including Neotrombicula autumnalis, Sarcoptes spp. and Cheyletiella spp. Treatment with FRONTLINE Spay has been shown to result in a significant reduction in the incidence of flea allergy dermatitis in both dogs and cats. When used as part of a strategy for the treatment of flea allergy dermatitis, monthly applications to the allergic patient and to other cats and dogs in the household are recommended. FRONTLINE Spray is active for up to 3 months against fleas in dogs and up to 2 months in cats depending on the environmental challenge. It is effective against tick infestations for up one month in dogs and cats, depending on the level of environmental challenge.

Puppies and kittens from 2 days of age may be safely treated.

FRONTLINE Spray does not prevent all ticks attaching to the animal, but ticks will be killed within the first 24 - 48 hours. Once dead, ticks will often drop off the animal, but any remaining ticks may easily be removed by a gentle pull, preferably using tweezers. There may be an attachment of single ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.

Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid reduction in environmental challenge and maximise the duration of protection against re-infestation provided by the product. FRONTLINE Spray is not suitable for direct treatment of the environment.

Bathing or shampooing up to four times in two months has been shown to have no significant effect on the residual efficacy of FRONTLINE Spray. Monthly treatment is recommended when more frequent shampooing is carried out. (Refer also to the 'Warnings' section of this data sheet).

In the absence of specific tolerance and efficacy data, FRONTLINE Spray is not recommended for the treatment of species other than cats and dogs.