For animal treatment only.

Do not vaccinate unhealthy chickens or chickens under heavy stress conditions. Do not use in broilers.

The use of the vaccine in fancy breeds has not been studied.

Due to the adenine-histidine auxotrophy of the vaccine strain, a differentiation between vaccine and field strains is possible by means of an appropriate growth test.

The vaccine strain is among others sensitive to ampicillin, cefotaxime, chloramphenicol, ciprofloxacin, gentamycin, kanamycin, oxytetracycline, streptomycin.

The vaccine strain is resistant to sulfamerazine alone but sensitive to sulfamerazine and trimethoprime in combination.

The vaccine strain can also be distinguished from the field strain by molecular biology methods, such as restriction fragment polymorphism (RFLP) in pulse gel electrophoresis (PFGE).

The vaccine strain has been shown to spread to non-target species such as calves and pigs. It persisted in these animals and was excreted over a period of 9 days in calves and 22 days in pigs and has been shown to cause a transient increase in body temperature.

Not to be used within 3 weeks (after the third vaccination) or 6 weeks (after the second vaccination) before the onset of lay and during the laying period.

Birds intended for lay should not come into contact with vaccinated birds for 3 weeks following vaccination.

No anti-infective substances should be used within 3 days before and after immunisation with the vaccine. In case of essential administration, the vaccination of the concerned birds has to be repeated.

No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. Therefore the safety and efficacy of this product when used with any other (either when used on the same day or at different times) has not been demonstrated.

No competitive microflora preparations should be administered concurrently with the product.

Administration of an overdose (10 doses) can occasionally result in loose faeces and in a transient weight loss without any effects on the final performances.

Vaccinated chickens excrete the vaccine strain up to six weeks post vaccination. The vaccine may thus spread to susceptible birds in contact with vaccinated chickens.

Use disposable gloves when reconstituting the vaccine. Wash and disinfect hands after handling vaccine.

Do not ingest. If the vaccine has been swallowed seek medical advice. The vaccine strain is sensitive to antibiotics with the exception of sulfamerazine.

Immunocompromised personnel should not handle the vaccine or come into contact with vaccinated chickens during the period of excretion of the vaccine strain.

The vaccine strain has been isolated from chicken litter up to 13 days after vaccination and is excreted from vaccinated chickens up to 19 days post vaccination. The vaccine strain can be found in the environment for up to 8 weeks after the 2nd vaccination and 5 weeks after the 3rd vaccination.

Personnel involved in attending vaccinated flocks should follow general hygiene principles (changing clothes, wearing gloves, cleaning and disinfection of boots) and take particular care in handling litter from recently vaccinated chickens. Hands should be washed and disinfected after attending vaccinated flocks.

Appropriate veterinary and husbandry measures should be taken to avoid spread to susceptible species.

Meat: 6 weeks from last vaccination.

Eggs: After the two first vaccinations: 6 weeks

After the third vaccination: 3 weeks