Following intravenous injection in the horse, the onset of musculo-skeletal anti-inflammatory activity occurs by 2 hours and reaches a peak at about 12 hours. It is still measurable 24 hours after each dose.

No clinical signs were observed when KETOFEN 10% was administered to horses at 5 times the recommended dose for 15 days, to cattle at 5 times the recommended dose for 5 days, or to pigs at 3 times the recommended dose for 3 days.

Horses have been found to tolerate intravenous dosages of ketoprofen of 2.2, 6.6 and 11.0 mg/kg once daily for 15 consecutive days (i.e. up to 5 times the recommended dose for three times the recommended duration) with no evidence of toxic effects.

Ketoprofen is similarly well tolerated in cattle, where doses of up to 15 mg/kg/day (5 times the recommended dose) for 5 consecutive days have been given without significant adverse effects. The product has been safely given to calves as young as 3 days of age, and to pregnant and lactating cattle.

Ketoprofen is well tolerated in pigs. Doses of 9mg/kg/day (3 times the recommended dose) for 3 consecutive days have been given with no significant adverse effects.

In common with all NSAIDs, due to their action of inhibition of prostaglandin synthesis, there can be the possibility in certain individuals of gastric or renal intolerance.

KETOFEN 10% (ketoprofen), in common with other non-steroidal anti-inflammatories, is not permitted by the Racing Authorities of Great Britain & Ireland to be used at the time of racing. Ketoprofen or its conjugates can be detected in urine for up to 10 days after treatment (analytical sensitivity of 50 ng/ml). An interval of 15 days from cessation of treatment should ensure that the drug is undetectable in most horses.