Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. Immediately following subcutaneous injection, activity suggesting pain, sometimes intense but usually transient, has been observed in some sheep. Mild and transient pain reactions may be seen in some pigs following subcutaneous injection. All of these reactions have disappeared without treatment.

In cattle, single doses of 4mg ivermectin per kg (20 x the usual level) given subcutaneously resulted in ataxia and depression. In sheep, dose levels up to 4mg per kg (20 x the usual level) given subcutaneously resulted in ataxia and depression. In pigs, a dose of 30mg ivermectin per kg (100 x the recommended dose) injected subcutaneously into pigs caused lethargy, ataxia, bilateral mydriasis, intermittent tremors, laboured breathing and lateral recumbency. No antidote has been identified, however, symptomatic therapy may be beneficial.

PANOMEC Injection has been used concurrently without adverse effects with clostridial vaccine, given at separate injection sites. Adequate vaccination of sheep against clostridial infections is strongly recommended.

Ivermectin belongs to the avermectin (3-AV) class of anthelmintic endectocides.