Do not administer the product to pigs receiving ionophores.

Valnemulin should not be administered to rabbits because of its toxicity in this species.

Medication of pigs with Econor has led to the occurrence of adverse reactions in the EU. Of the cases reported in 1999 to 2000, the majority occurred in Denmark and Sweden (one case each in Finland and Ireland). In these countries, the incidence ranged from 0.03 to 1.76% of all pigs treated. On affected farms, one third of the pigs were affected, with a mortality of 1%. Affected pigs are pyrexic, exhibit inappetence, and in severe cases become uncoordinated, ataxic and may become recumbent. A percentage of such pigs may also suffer oedema or erythema (posterior in distribution), and palpebral oedema. The reaction has been studied in controlled trials in susceptible animals. Mortality was less than 1%, but might be increased as a result of secondary infections.

In the case of a adverse reaction, immediate withdrawal of medication is recommended. Severely affected pigs should be removed to clean dry pens and given symptomatic treatment, including treatment for concurrent disease.

An epidemiological survey has indicated that there is likely to be an association between the susceptibility to adverse reactions and the Danish and Swedish Landrace breeds, and their crossbreeds thereof, especially younger pigs.

Valnemulin is well-accepted in feed, but administered at concentrations above 200 mg/kg feed may result in transient reduction in food consumption associated with unpalatability during the first few days of feeding.

If you notice any other side effects, please inform your veterinary surgeon.

For animal treatment only.

Valnemulin has been shown to interact with the ionophores such as monensin, salinomycin and narasin and may result in signs indistinguishable from an ionophore toxicosis. Animals should not receive products containing monensin, salinomycin or narasin, during or at least 5 days before or after treatment with valnemulin. Severe growth depression, ataxia, paralysis or death may result.

Whilst studies in rats and mice have not produced any evidence of teratogenic effect, the safety during pregnancy and lactation has not been established in pigs.

When mixing the product and handling the final feed containing the product, direct contact with the skin and mucous membranes should be avoided. In case of accidental ingestion, seek medical advice immediately and show the product label. People with known hypersensitivity to valnemulin should administer the product with caution.

Adverse drug reactions have occurred following use of Econor. Their occurrence may be principally restricted to the Scandinavian countries and appears mainly to be associated with breed mixes that include Danish and/or Swedish Landrace. Extreme care should therefore be taken in the use of Econor in pigs of Scandinavian origin especially of the Danish and Swedish Landrace breeds, and their crossbreeds thereof.

Any unused product or waste material should be disposed of in accordance with local requirements.

1 day.