PROGRAM PLUS tablets are administered at a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.

PROGRAM PLUS tablets are available in four sizes and are given according to the weight of the dog.

For dogs greater than 45 kg, a combination of tablets is given, consistent with the recommended minimum dose.

PROGRAM PLUS tablets should be administered in the following situations:

To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection medication should start from 2 weeks of age, or from a minimum weight of 1 kg.

PROGRAM PLUS can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.

In puppies, medication with PROGRAM PLUS is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (PROGRAM).

To prevent flea infestations and heartworm disease at the same time, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.

Dogs in a heartworm region:To prevent flea infestations and heartworm disease at the same time, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.

If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

To ensure adequate drug absorption, PROGRAM PLUS tablets must be administered with food (for example mixed with the daily feed) or placed directly in the mouth after feeding.

Treatment with PROGRAM PLUS tablets may begin at any time of the year. In geographic areas where the presence of fleas and mosquitoes (heartworm vector) is seasonal, depending on ambient temperature, treatment should be started one month prior to the appearance of the insects and then repeated monthly throughout the risk period. In environments with year-round flea infestations and concurrent heartworm risk, treatment may be continued throughout the year without interruption.

Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.

PROGRAM PLUS tablets immediately block the reproductive cycle of fleas by inhibiting the development of eggs and larvae. Pre-existing generations (e.g. pupae) present in the environment can, however, continue to develop and emerge for several weeks after the start of treatment.