For intramuscular injection. Atipamezole (Antisedan) is quickly absorbed and is generally administered 15–60 minutes after the medetomidine or dexmedetomidine.

The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg) is five times that of the previous medetomidine dose or 10 times that of the previous dexmedetomidine. Thus an equal volume of Antisedan to that of the previously administered medetomidine or dexmedetomidine should be given.

Where Domitor (medetomidine) or Dexdomitor (dexmedetomidine) has been used, with or without butorphanol, as a premedicant to thiopentone, halothane anaesthesia in dogs, or as a premedicant to propofol anaesthesia in dogs, Antisedan may be administered in the post-operative phase to reverse the effects of Domitor or Dexdomitor and hasten recovery. Thus an equal volume of Antisedan to that of the previously administered medetomidine should be given. Antisedan in the post-operative phase rapidly causes arousal to full awareness and thus radically reduces the period of possible cardiovascular depression and hypothermia.

The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg) is two-and-a-half times that of the previous medetomidine dose or 5 times that of the previous dexmedetomidine dose. Thus half the volume of Antisedan to that of the previously administered medetomidine or dexmedetomidine should be given.

The dose of Antisedan, in micrograms per kilogram (mcg/kg) should not exceed four times that of the previously administered medetomidine or 8 times that of dexmedetomidine.

When cats have been anaesthetised with Domitor (medetomidine) or Dexdomitor (dexmedetomidine), with or without butorphanol, and ketamine, or Domitor or Dexdomitor and alfaxalone/alfadolone, Antisedan 5 mg/ml solution may be administered to reverse the effects of Domitor or Dexdomitor and so speed recovery from anaesthesia. Thus half the volume of Antisedan to that of the previously administered Domitor (medetomidine) or Dexdomitor (dexmedetomidine) should be given.