Antisedan has only been administered to a limited number of pregnant dogs and cats and therefore cannot be recommended in pregnancy.

In dogs, a transient hypotensive effect has been observed during the first ten minutes post-injection.

Vomiting, panting, defaecation and muscle tremors (possibly shivering) have been reported, but these effects appear to be rare.

In dogs when a combination of butorphanol, Domitor or Dexdomitor and ketamine has been used Antisedan should not be used.

In cats, when using low doses of Antisedan to partially reverse the effects of medetomidine or Dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.

No harmful interactions with other agents have been encountered in clinical trials. However, concurrent use of drugs affecting the CNS is not recommended, apart from those in the data sheet.

Transient over-alertness and tachycardia may be observed after a possible overdosage. Over-alertness in the cat is best handled by minimising external stimuli.

Due to the potent pharmacological effect of Antisedan, skin contact should be avoided and impervious gloves should be worn during administration. Care should be taken to avoid accidental self-injection. If accidental self-injection occurs, seek immediate medical attention showing a copy of the product literature. Do not drive. The patient should not be left unattended. In case of accidental spillage, wash the affected area immediately with clean running water. Seek medical attention if irritation persists. In case of accidental ingestion, seek medical advice immediately.