The dose rate 4–10 mg/kg (2–5 mg/lb) twice daily is recommended. In severe or acute conditions these levels may be increased and/or repeated at more frequent intervals at the clinician's discretion. The following is intended as a guide:

Because of the high blood levels rapidly achieved after oral dosing, parenteral antibiotic treatment has generally been found to be unnecessary even in the presence of systemic infection. However, where parenteral treatment is required, the tablets may be useful as follow-up therapy.

Clamoxyl Palatable Tablets are often accepted from the hand, even by sick cats and dogs. Alternatively the tablets may be crushed and added to a little feed.