Before using any combinations consult the contraindications and warnings that appear on the other products' data sheets.

The use of Domosedan in conjunction with sympathomimetic amines is contra-indicated.

Do not use in horses in the last month of pregnancy.

Withdrawal period: 1 day.

The concurrent use of certain potentiated sulphonamides may cause potentially fatal dysrhythmias. Whilst this effect is under investigation it is recommended that potentiated sulphonamides are not administered during sedation with Domosedan.

Intravenous administration should be slow.

Administration of Domosedan may cause benign, reversible cardiac arrhythmia, incoordination of the limbs and sweating. Slight tremor of individual muscles or muscle groups may occasionally be observed.

Domosedan must not be mixed with other products.

Antidiuretic effect is usually observed within 45 to 60 minutes after treatment. The product should not be used in horses with pre-existing AV blocks, with severe coronary insufficiency or chronic renal failure. Careful consideration should be given to administration to animals in shock and to animals with liver or kidney disease.

Horses should not be given water or food before the drug effect has passed.

It is always necessary to administer Domosedan prior to ketamine and allow sufficient time (5 minutes) for sedation to develop. The two agents will therefore never be administered simultaneously in the same syringe.

It is recommended that feed should be withheld for at least 12 hours prior to anaesthesia.

Excitable horses are sometimes poor subjects for anaesthesia. It is a prime requisite that the horse should be quietly and carefully handled during the administration of the anaesthetic agents so as to ensure the minimum amount of upset during the induction period. If the horse fails to become sedated following the injection of Domosedan, then ketamine should not be injected and the anaesthetic procedure should be abandoned.

Do not use for horses intended for human consumption. Do not use in horses with a history of liver disease. The combination should not be used in pregnant animals or in animals suffering from colic.

Routine cardiac auscultation should be performed prior to use of this combination.

Do not use the combination in horses with a preexisting cardiac dysrhythmia or bradycardia. Mild to severe ataxia may be encountered but clinical studies have shown that horses are unlikely to collapse. Normal precautions should be observed to prevent patient self-injury.

Wear protective rubber gloves when using this product.

Wash off splashes from the skin and eyes.

In the event of accidental self-administration seek medical advice and show the label and other product literature, but DO NOT DRIVE as changes in blood pressure may be seen.

Domosedan is an alpha 2 adrenergic agonist. Care should be taken to avoid accidental self-injection.

For animal use only. Keep out of the reach of children.