Do not administer to an animal previously found to be hypersensitive to ceftiofur and other β-lactam antibiotics. Do not inject intravenously.

Even though studies in laboratory animals show no evidence of teratogenesis, abortion or influence on reproduction, the reproductive safety of ceftiofur has not been specifically investigated in pregnant sows or cows. Use only according to a benefit/risk assessment by the attending veterinary surgeon.

Hypersensitivity reactions unrelated to dose can occur. Allergic reactions (e.g. skin reactions, anaphylaxia) may occasionally occur.

In the case of an allergic reaction the treatment should be withdrawn.

Inappropriate use of the product may increase the prevalence of bacteria resistant to cephalosporins.

Use of the product should be based on susceptibility testing and take into account official and local antimicrobial policies.

In cattle, mild inflammatory reactions at the injection site, such as tissue oedema and discolouration of the subcutaneous tissue and/or fascial surface of the muscle may be observed. Clinical resolution is reached in most animals by 10 days after injection although slight tissue discolouration may persist for 28 days or more. In cattle, no signs of systemic toxicity have been observed following substantial parenteral overdosages.

In pigs, mild reactions at the injection site such as discolouration of the fascia or fat have been observed in some animals for up to 20 days after injection.

The low toxicity of ceftiofur has been demonstrated in swine using ceftiofur sodium at doses in excess of 8 times the recommended daily dose of ceftiofur administered intramuscularly for 15 consecutive days.

Animals must not be slaughtered for human consumption during treatment.

Zero days.

Milk for human consumption may be taken during and after last treatment.

Cattle may be slaughtered for human consumption only after 8 days from last treatment.

Pigs may be slaughtered for human consumption only after 5 days from last treatment.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious: