For active immunisation of cattle to reduce infection, clinical signs and respiratory disease caused by Bovine Respiratory Synctial Virus (BRSV), Infectious Bovine Rhinotracheitis (IBR, caused by BHV-1) virus and Parainfluenza type 3 Virus (PI3); and leucopenia and viraemia caused by the Bovine Viral Diarrhoea (BVD) virus Type 1 cytopathic and non-cytopathic strains. A duration of immunity of at least 6 months has been demonstrated.