Introduction

Company name: Pfizer Limited

Address: Ramsgate Road

Sandwich

Kent CT13 9NJ

Telephone: 0845 300 8034 (Out of hours: 01304 616161)

Fax: 01737 332521

Email: UKVetLine@pfizer.com

Website: www.only4vets.co.uk

Presentation

Clamoxyl Palatable Tablets are prepared as speckled off-white flat circular tablets with a break-line on one face. The tablets contain either 40 mg or 200 mg amoxicillin as Amoxicillin trihydrate in a highly palatable base.

Uses

Clamoxyl is a broad spectrum semi-synthetic penicillin which is bactericidal against a wide range of Gram-positive and Gram-negative bacteria found in dogs and cats including the following: Haemophilus spp., Pasteurella spp., Proteus mirabilis, Salmonella spp., Leptospira spp., Escherichia coli, streptococci and staphylococci (penicillin-sensitive strains),

Clamoxyl may be effective in the following indications: localised infections, alimentary tract infections, respiratory infections, urogenital tract infections, secondary bacterial infections and generalised infections.

Dosage and administration

The dose rate 4–10 mg/kg (2–5 mg/lb) twice daily is recommended. In severe or acute conditions these levels may be increased and/or repeated at more frequent intervals at the clinician's discretion. The following is intended as a guide:

Cats	½–1×40 mg tablet twice daily
Dogs per 10 kg	1–2×40 mg tablets twice daily
or per 20 kg	½–1×200 mg tablet twice daily

Because of the high blood levels rapidly achieved after oral dosing, parenteral antibiotic treatment has generally been found to be unnecessary even in the presence of systemic infection. However, where parenteral treatment is required, the tablets may be useful as follow-up therapy.

Clamoxyl Palatable Tablets are often accepted from the hand, even by sick cats and dogs. Alternatively the tablets may be crushed and added to a little feed.

Contra-indications, warnings, etc

For animal treatment only.

In common with all penicillins Clamoxyl should not be given to penicillin-sensitive animals.

Clamoxyl should not be used orally or parenterally in rabbits, guinea pigs, hamsters or gerbils. Caution is advised in its use in any other very small herbivores.

Operator warnings

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

Handle this product with great care to avoid exposure, taking all recommended precautions.

Wash hands after use.

If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.

Pharmaceutical precautions

Store in a dry place. Do not store above 25°C

Keep out of the reach of children.

Any unused product or containers should be disposed of in accordance with any national requirements. Return any unused product to the veterinary surgery or local pharmacy.

Legal category

POM-V

Packaging Quantities

Securitainers of 500×40 mg and 250×200 mg. Blister packs containing 100×40 mg are also available.

Further information

The following features of Clamoxyl Palatable Tablets warrant special mention:

1.Oral absorption is particularly good.

2.After absorption amoxicillin is widely distributed throughout the tissues with especially high levels in the kidney, urine, liver and bile.

3.It shares with other penicillins the virtual absence of toxicity problems even at very high dose levels.

Marketing authorisation numbers

40 mg Tablets	Vm 00057/4145
200 mg Tablets	Vm 00057/4146