Introduction

Pfizer

Company name: Pfizer Limited

Address: Ramsgate Road

Sandwich

Kent CT13 9NJ

Telephone: 0845 300 8034 (Out of hours: 01304 616161)

Fax: 01737 332521

Email: UKVetLine@pfizer.com

Website: www.only4vets.co.uk

Presentation

Dermisol Cream is a white cream for topical application. The product is prepared from the following active ingredients:

Propylene Glycol	1.750% v/v
Malic acid	0.375% w/v
Benzoic Acid	0.025% w/v
Salicylic Acid	0.006% w/v

Uses

Dermisol Cream may be used to encourage healing in horses, cattle, dogs and cats particularly when this process is impaired by the presence of necrotic tissue, coagulum, debris or wax. This may occur in cases of traumatic injury, surgical wounds, infected wounds and otitis externa.

Action

Dermisol Cream aids healing by removing dead and necrotic tissue from affected areas.

This is achieved by differential swelling of necrotic and healthy tissues leading to separation of the devitalised areas and embedded debris.

Dosage and administration

Dermisol Cream is for topical use only. Dermisol Cream should be applied twice daily although more frequent applications may be made if necessary.

Wounds: The cream should be spread liberally on to wound surfaces and before each new application it is advisable to wash the area with Dermisol Multicleanse Solution so that loose slough and cream from the previous application are removed without raising the pH.

Otitis externa: In cases of otitis externa, ears should be cleaned with Dermisol Multicleanse Solution prior to the introduction of Dermisol Cream into the external auditory canal.

Contra-indications, warnings, etc

For external use only. For topical use only Care should be taken to avoid contact with the eyes because of the low pH and a possible irritant effect. If contact occurs, rinse with clean, fresh water. May cause skin irritation. It is recommended that gloves be worn when handling the product if you have sensitive skin. Wash hands after use.

When used for treating udder lesions in cattle, the udder and the teats should be washed immediately before the next milking.

Do not use in conjunction with other products, e.g. teat dips, udder disinfectants, etc. as these will almost certainly neutralise and reduce the effectiveness of Dermisol.

Do not use in the treatment of otitis externa in animals with a ruptured ear drum.

Withdrawal periods

Cattle:	meat - zero days.
	milk - zero hours.
Horses:	meat - zero days.

Pharmaceutical precautions

Do not store above 25°C.

Prolonged contact with metal surfaces is inadvisable.

Keep out of the reach of children. For animal treatment only. Dispose of empty packaging and any remaining product in the household or farm refuse.

Legal category

POM-VPS

Packaging Quantities

Dermisol Cream is available in 30 g and 100 g tubes.

Further information

Dermisol aids the removal of dead tissue and any embedded debris by causing maximum differential swelling between live and dead areas.

This is achieved in two ways:

1.The low pH causes separation of collagen molecules by rupturing the hydrogen bonding. The optimum pH to achieve this effect is between pH 2 and pH 3.

2.The organic acid reacts with carboxyl and amino groups in the collagen. The insertion of the organic acid forces the collagen chains apart.

In both cases the devitalised tissues absorb water and swell markedly.

Healthy tissue is unaffected because of natural barriers to organic acids and sufficient buffering capacity to maintain a near neutral pH.