Marbocyl Bolus: Contra-indications, warnings, etc
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Marbocyl Bolus
Contra-indications, warnings, etc
Do not exceed the recommended duration of treatment (3 days).
Withdrawal periods
Meat: 6 days.
The product is not indicated for use in lactating animals.
At the recommended dosage, no undesirable effect is expected. At twice the dosage, a reversible, short term decease of the intestinal Enterobacteriaceae population can occur, as well as faecal softening, but without clinical consequence as the balance of aerobes/anaerobes is not affected.
At four times the recommended dosage, a marked decrease in the intestinal Enterobacteriaceae population has been observed but this is reversible. At higher dosages, as is known for other oral antibiotics administered to neonatal animals, symptoms in the form of diarrhoea can occur. Further administration of marbofloxacin must be stopped and the symptoms treated symptomatically.
When administration is carried out using an applicator, care should be taken to avoid soft tissue injury.
Concurrent administration of oral preparations which contain a high proportion of divalent cations may reduce marbofloxacin activity.
Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, to other classes of antimicrobials. Whenever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Operator warning
People with known hypersensitivity to fluoroquinolones should avoid using this product. Wash hands after use.
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Date updated: 4 December 2007