Do not use in dogs with low blood pressure.

Do not use in dogs with acute renal insufficiency.

Do not use in dogs with congenital heart disease

Do not use in dogs hypersensitive to an ACE inhibitor

Do not use in dogs with haemodynamically relevant stenoses (aortic stenosis, mitral valve stenosis, pulmonal stenosis)

Do not use in dogs with obstructive hypertrophic cardiomyopathy

Diarrhoea, hypotension and related symptoms such as fatigue, dizziness or anorexia can occur in rare cases. Vomiting can also occur in very rare cases. In such cases treatment should be discontinued until the patient's condition has returned to normal.

The use of ACE inhibitors in dogs with hypovolaemia/dehydration can lead to acute hypotension. In such cases the fluid and electrolyte balance should be restored immediately and treatment suspended until it has been stabilised. Parameters used for monitoring renal function should be checked at the beginning of the treatment and at regular time intervals thereafter.

In the absence of data, do not use in pregnant or lactating bitches or in breeding dogs.

However diuretics and a low sodium diet potentiate the effect of ACE inhibitors by activating the renin-angiotensin-aldosterone system (RAAS). Diuretics used at high doses and a low sodium diet are thus not recommended during a treatment with ACE inhibitors in order to avoid hypotension with clinical signs such as apathy, ataxia, rare syncope and kidney failure. In case of joint administration with potassium retaining diuretics, potassium must be monitored because there is a risk of hyperkaliemia

Oral doses up to 5 mg/kg of imidapril (20 times the recommended dose) have been well tolerated in healthy dogs. Hypotension may occur as a symptom of overdosage with signs of apathy and ataxia. The treatment is symptomatic.

Not applicable