Mice: 0.01 ml/30 g body weight (0.105 mg/kg body weight fentanyl citrate and 3.333 mg/kg body weight fluanisone) by intraperitoneal injection.

Rats: 0.4 ml/kg body weight (0.126 mg/kg body weight fentanyl citrate and 4 mg/kg body weight fluanisone) by intramuscular or intraperitoneal injection.

Rabbits: 0.5 ml/kg body weight (0.158 mg/kg body weight fentanyl citrate and 5 mg/kg body weight fluanisone) by intramuscular injection.

Guinea pigs: 1 ml/kg body weight (0.315 mg/kg body weight fentanyl citrate and 10 mg/kg body weight fluanisone) by intramuscular injection.

The duration of sedation and immobilisation is approximately 30-60 minutes. Analgesic effects may persist.

Mice: 0.01 ml Hypnorm /30 g body weight (0.105 mg/kg body weight fentanyl citrate and 3.333 mg/kg body weight fluanisone) by intraperitoneal injection with 5 mg/kg body weight diazepam by intraperitoneal injection.

Rats: 0.3ml Hypnorm/kg body weight (0.095 mg/kg body weight fentanyl citrate and 3 mg/kg body weight fluanisone) by intramuscular injection with 2.5 mg/kg body weight diazepam by intraperitoneal injection.

Rabbits: 0.3 ml Hypnorm/kg body weight (0.095 mg/kg body weight fentanyl citrate and 3 mg/kg body weight fluanisone) by intramuscular injection with 2 mg/kg body weight diazepam by intraperitoneal or intravenous injection.

Guinea pigs: 1 ml Hypnorm/kg body weight (0.315 mg/kg body weight fentanyl citrate and 10 mg/kg body weight fluanisone) by intramuscular injection with 2.5 mg/kg body weight diazepam by intraperitoneal injection.

This combination of drugs provides good surgical anaesthesia with muscle relaxation for about 20-40 minutes.

Clinical experience has shown that at appropriate dilutions, midazolam is miscible with Hypnorm. Midazolam 5 mg/ml and Hypnorm are each diluted with an equal volume of Water for Injection prior to mixing. The resulting mixture contains 1.25 mg/ml midazolam, 2.5 mg/ml fluanisone and 0.079 mg/ml fentanyl citrate and is administered as a single intraperitoneal injection.

Mice: 10 ml/kg body weight

Rats: 2.7 ml/kg body weight

Guinea pigs: 8 ml/kg body weight

Rabbits: 0.3 ml Hypnorm/kg body weight (0.095 mg/kg body weight fentanyl citrate and 3 mg/kg body weight fluanisone) by intramuscular injection with 2.0 mg/kg body weight midazolam by intraperitoneal injection.

This combination of drugs provides good surgical anaesthesia with muscle relaxation for about 20-40 minutes.