Zero days.

There are no absolute contra indications.

It should be noted that ACD-A is an excipient and that excess citrate may cause a reaction in the recipient foal. This may be seen as muscle fasciculations, weakness and cardiac abnormalities

Transfusion Reactions are very rare; signs include tachycardia, hyperventilating and trembling.

Anaphylaxis is very rare, but can occur with products of this nature. Signs include tachycardia, hyperventilating and trembling, or other signs such as colic, pyrexia, cardiac arrhythmias, urticaria and collapse.

Volume Overload is a very rare but possible hazard of plasma transfusion especially if the administration is carried out too quickly. Signs include respiratory distress, hyperventilation, staggering and collapse when in standing restraint. Additionally, if the foal is in lateral recumbency froth may be seen at the nostril.

If tachycardia, hyperventilating or trembling occurs, slow the transfusion down or stop altogether. If signs abate within five minutes, as they should, then continue transfusing. If they recur again, stop entirely. If severe, or other signs occur such as colic, pyrexia, cardiac arrhythmias, urticaria and collapse, stop transfusion and if necessary administer epinephrine (0.01mg/kg), corticosteroids and intravenous saline. These emergency drugs should always be on hand. Flunixin meglumine at 0.25mg/kg may be used prophylactically to reduce the incidence of side effects.

Do not mix other products with HYPERMUNE-RE, and use straight from the bag.

Do not administer more than 2 doses to any one animal.

It is recommended that no other immunological product be administered within 14 days following administration of Hypermune-RE apart from tetanus antitoxin which may be administered simultaneously but not intravenously. As with colostrum derived passive immunity, the passive immunity transferred by Hypermune-RE may interfere with response to vaccine. It is recommended that this is considered when starting a vaccine programme with due adherence to the vaccine manufacturer's instructions.