STORAGE: Frozen at –25ºC ± 5oC. HYPERMUNE-RE should be handled carefully when being unpacked and stored in the freezer. The bubble-wrap should not be removed as it protects the brittle frozen plastic which is susceptible to damage from careless handling such as being dropped or knocked in the freezer. When thawed it should be stored in a refrigerator and used within 24 hours. Do not use after the expiry date stated on the label.

Keep out of the sight and reach of children.

Thawing should not take place in a microwave oven. The litre bag of plasma should be immersed only in warm water at not more than 40ºC. A water bath such as a sink full of domestic warm water is ideal. As the plasma thaws and the water cools, more warm water may be added as required but hot water (not greater than hand hot) must be avoided as it will damage the proteins. The entire litre of plasma should be brought slowly to body temperature before use to ensure all the cryoprecipitate is dissolved. Under optimum conditions this whole process may take 2-2½ hours. Occasionally small amounts of fibrin may still be seen floating in the plasma. It is not significant but must be filtered out by the filter in the blood administration set.

Inspect for leakage and if apparent on thawing the entire contents must be discarded.

Unused product and empty pack should be discarded and disposed of as clinical waste.