It must be remembered that progestagens, like other synthetic hormones, should always be used with care. This is particularly so in bitches treated at their first oestrus. Owners should be advised that this class of bitch, and a small proportion of others which have abnormal oestrus cycles, may show excessive libido, or oestrus may return earlier than expected, because of difficulties which may be encountered with the timing of administration.

Apart from these considerations experience has shown that, when used correctly, Ovarid Tablets do not produce undesirable side effects since oral administration allows the duration of effect to be more accurately controlled than is the case with depot injections.

In the prevention of oestrus in bitches, the timing of administration is of great importance if the best results are to be obtained. If Ovarid Tablets are given once ovulation has occurred, they may aid conception.

Ovarid is not recommended in diabetic animals.

Occasionally, lethargy and increased appetite with consequent weight gain may be seen in treated animals.

As with all progestagens there is the possibility of endometrial changes. However, at the recommended doses of Ovarid there should be no adverse effects.

Very occasionally, following the long-term use of megestrol acetate in cats to prevent the recurrence of miliary eczema, mammary hypertrophy may occur. This effect is quite distinct from mammary neoplasia and may regress on cessation of dosing. In such cases medication should be withdrawn.

Male dogs intended for breeding should not be treated with Ovarid.

Dispose of used packaging in the household refuse. Unused product should be returned to the veterinary surgeon.