Pharmacotherapeutic group: penicillins with extended spectrum. ATCvet code: QJ01CA04.

Amoxicillin is a semi-synthetic penicillin derived from the 6 APA core (6 amino-penicillic acid). It is a broad-spectrum antibiotic, bactericidal against gram + and gram - bacteria, in particular Actinobacillus pleuropneumoniae, isolated in pigs.

Amoxicillin acts by inhibition of bacterial cell wall synthesis or activation of enzymes disrupting cell walls (bactericidal action).

In pigs, after the administration of Stabox 50% Oral Soluble Powder Pig at a dose of 20 mg/kg in liquid feed, amoxicillin maximal plasma concentration of 2.0 μg/ml is reached 1.8 hours after the administration. The repeated administration of the drug does not lead to accumulation. The average absolute bioavailability of amoxicillin in liquid feed is estimated to be 12%.