Do not use on cats.

This product is extremely poisonous to cats and could be fatal due to the unique physiology of this species which is unable to metabolise certain compounds, including permethrin. To prevent cats from being accidentally exposed to the product, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog which has been treated with this product. Seek veterinary advice immediately if this occurs.

In the absence of available data, the product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight.

Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.

Care should be taken to avoid the contents of the pipette coming into contact with the eyes or mouth of the recipient dogs.

Care should be taken to administer the product correctly as described above, under Method of Administration. In particular, oral uptake due to the licking of the application site by treated or in-contact animals should be avoided.

Consult your veterinary surgeon before using the product on sick and debilitated dogs.

On very rare occasions reactions in dogs may include transient skin sensitivity (increased local itching, scratching and rubbing, hair loss and redness at the application site) or lethargy that are generally self resolving.

In very rare cases dogs may show behaviour changes (agitation, restlessness, whining or rolling), gastro-intestinal symptoms (vomiting, diarrhoea, hypersalivation, diminished appetite) and neurological signs such as unsteady movement and twitching in dogs susceptible to the ingredient permethrin. These signs are generally transient and self-resolving.

Poisoning following inadvertent oral uptake in dogs is unlikely but may occur in very rare cases. In this event, neurological signs such as tremor and lethargy can occur. Treatment should be symptomatic. There is no known specific antidote.

There may be an attachment of single ticks or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable. However, the product provides repellent (anti-feeding) activity against ticks, sand flies and mosquitoes, thus preventing the repelled parasites from taking a blood meal and thus reducing the risk of Canine Vector-Borne Disease (CVBD) transmission (e.g. borreliosis, rickettsiosis, ehrlichiosis, leishmaniosis). No adverse clinical signs were noted in healthy puppies or adult dogs exposed to 5x overdosage or for puppies whose mothers were treated with 3x overdosage of the product.

The solvent in Advantix Spot-on solution may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Avoid contact between the product and skin, eyes or mouth.

Do not eat, drink or smoke during application.

Wash hands thoroughly after use.

In case of accidental spillage on to skin, wash off immediately with soap and water.

People with known skin sensitivity may be particularly sensitive to this product. The predominant clinical symptoms that in extremely rare case may be shown are transient sensory irritations of the skin like tingling, burning sensation or numbness.

If the product gets accidentally into the eyes, they should be thoroughly flushed with water.

If skin or eye irritation persists, or if the product is accidentally swallowed, obtain medical attention immediately and show the package insert to the physician.

Treated dogs should not be handled, especially by children, until the application site is dry. This may be ensured by treating dogs when children are not present, eg in the evening. Recently treated dogs should not be allowed to sleep together with their owner, especially children.

The product should not be allowed to enter water courses, as this may be dangerous for fish and aquatic organisms.

Treated dogs must not under any circumstances be allowed to enter into any type of surface water for at least 48 hours after treatment.

Permethrin containing products are toxic to honey bees.

Any unused product or waste material should be disposed of in accordance with national requirements.