The recommended minimum dose is:
10 mg/kg body weight imidacloprid and 50 mg/kg body weight permethrin.
For dermal use only. Apply only to undamaged skin.
Please refer to Table 1 for the dosing scheme for Advantix Spot-on.
Dosage and Treatment Schedule
Imidacloprid (mg/kg bw)
Permethrin (mg/kg bw)
≤ 4 kg
Advantix Spot-on for dogs up to 4 kg
minimum of 10
minimum of 50
>4 kg up to ≤ 10 kg
Advantix Spot-on for dogs over 4 kg up to 10 kg
10 - 25
50 - 125
>10 kg up to ≤ 25 kg
Advantix Spot-on for dogs over 10 kg up to 25 kg
10 - 25
50 - 125
>25 kg up to ≤ 40 kg
Advantix Spot-on for dogs over 25 kg up to 40 kg
10 - 16
50 - 80
The appropriate combination of pipettes should be used
To reduce re-infestation from emergence of new fleas it is recommended that all dogs in a household be treated. Other pet animals living in the same household should also be treated with a suitable product. To further aid in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended.
The product remains effective if the animal becomes wet. However, prolonged, intense exposure to water should be avoided. In cases of frequent water exposure the persistent efficacy may be reduced. In these cases do not retreat more frequently than once weekly. If a dog requires a shampoo, it should be administered before applying Advantix or at least 2 weeks after application, to optimise efficacy of the product.
In case of biting louse infestation, a further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
To protect a dog over the whole sand fly season, treatment should be compliantly continued throughout.
Method of Administration
Remove one pipette from the package. Hold pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of the cap back on the pipette. Twist cap to break seal, then remove cap from pipette. See Figure 1.
Figure 1: Opening a pipette
Administration to dogs weighing 10 kg or less
With the dog standing still, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 2.
Figure 2: Administration to dogs up to 10kg
Administration to dogs weighing over 10 kg
With the dog standing still, the entire contents of the Advantix pipette(s) should be applied evenly to several spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution onto the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. See Figure 3.
Figure 3: Administration to dogs over 10 kg
Use during pregnancy and lactation
The product may be used during pregnancy and lactation.