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Pharmacological particulars
Pharmacotherapeutic group: Antidiarrheals, intestinal anti-inflammatory/anti-infective agents, intestinal anti-infectives, antibiotics.
ATC vet code: QA07AA51
Pharmacodynamic properties
Sulphadiazine is a broad spectrum antimicrobial agent. It acts by interfering with the biosynthesis of folic acid in bacteria cells, competitively preventing para-aminobenzoic acid (PABA) from incorporation into folic acid molecule.
Neomycin is the isomeric mixture of Neomycin Band C. It has a rapid dose related bactericidal action on susceptible microorganisms. The antibacterial action is directed primarily against aerobic gram negative bacteria.
Pharmacokinetic particulars
Sulfadiazine is rapidly absorbed from the gastrointestinal tract and widely distributed to all tissues and body fluids. The sulphonamides are eliminated by a combination of renal excretion and biotransformation.
Neomycin is poorly absorbed from the gastrointestinal tract, has a short half-life and is nearly all excreted unchanged from the gastrointestinal tract.