A clear, colourless to greenish-yellow solution for injection.

Cattle and Sheep.

For the treatment of cerebrocortical necrosis in cattle and sheep and as an adjunct in metabolic disorders of cattle.

Do not use in cases of known hypersensitivity to the active ingredient.

Not applicable.

Intravenous injections should be given slowly.

Observe aseptic techniques.

Care should be taken to avoid accidental self-injection. In the event of accidental self-injection, consult medical advice immediately and show the doctor this label. Wash hands after use.

Adverse effects are not anticipated following administration of thiamine.

It is not anticipated that the use of Vitamin B1 Injection will lead to any undesirable effects during pregnancy or lactation.

None Known.

By intramuscular or slow intravenous injections.

Dosage: 2.5 - 5ml per 50 kg bodyweight. Repeat every 3 hours for up to a total of 5 doses.

Thiamine is very soluble in water and excess is excreted in the urine as a pyrimidine or as unchanged material. Tolerance studies have been carried out at twice the maximum recommended dose and the product was well tolerated.

Meat - Zero days

Milk - Zero hours

Pharmacotherapeutic group: Vitamins, Vitamin B1, plain and in combination with vitamins B6 and B12, Vitamin B1, plain. ATC vet code: QA11DAO1.

Vitamin B1, also known as thiamine and as aneurine, is a water soluble vitamin. Aneurine is converted in the body to aneurine pyrophosphate (cocarboxylate) which acts as a coenzyme for several decarboxylating enzyme systems, the most important of which is decarboxylase. The enzyme is necessary for the decarboxylation of pyruvic acid, an intermediate stage in carbohydrate build-up or breakdown. When carbohydrates are a major source of energy the body requirements of aneurine increase. Deficiencies affect the nervous and gastrointestinal systems and skin.

Tissues dependent on glucose or lactate-pyruvate for energy such as the brain and heart are particularly compromised in thiamine deficiency. Thiamine deficiency may be primary, due to deficiency in the diet, or secondary, because of destruction of the vitamin in the diet by thiaminase. The principal cause of thiamine deficiency is the presence of thiamine-destroying agents which are widely distributed in nature, and produced by rumen microflora. Growing sheep are particularly susceptible, and outbreaks of cerebrocortical necrosis have been associated with sulphur in the diet.

Benzyl Alcohol

Sodium Hydroxide

Disodium Edetate

Water for Injection

None known.

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf-life after first opening the immediate packaging: 28 days.

Do not store above 25°C.

Protect from light.

Once broached, use vial within 28 days. Discard unused material.

50 ml amber type II glass vial with a red bromobutyl rubber bung and plain aluminium cap.

Any unused product or waste material should be disposed of in accordance with national requirements.

27th May 1993

October 2018

Nil