A clear green gel. 100g gel contains 50 000 IU of Heparin Sodium, 0.5g of Levomenthol and 5.0g of Hydroxyethyl salicylate.

For the treatment of local inflammatory swellings and bruising, including tendonitis, tenosynovitis, bursitis and other acute inflammatory conditions of the musculo-skeletal system in the horse.

Compagel also promotes the early reabsorption of haematoma and oedematous swelling resulting from such conditions.

Up to a total daily quantity of 50g gel per day is applied using finger tip pressure onto the affected area according to the veterinary surgeon’s instructions until signs and symptoms resolve.

Do not use in case of hypersensitivity to the active substances or to any of the excipients.

Do not apply to broken skin.

Do not apply to open wounds or fresh or encrusted skin lesions.

Avoid contact with the eyes or mucous membranes.

Avoid contact with open wounds or with the eyes. Impervious gloves should be worn when applying the product.

If side effects occur, treatment should be discontinued.

No overdose is known when the product is used topically as intended.

No clinical data are available on the topical use of Compagel during pregnancy. The use is not recommended during pregnancy and lactation.

Meat and Offal : 0 days.

Do not use in pregnant and lactating animals which are intended to produce milk for human consumption.

Shelf-life of the veterinary medicinal product as packaged for sale: 2 years

Shelf-life after first opening the container: 3 months. Discard any product remaining in the container at this time.

Do not store above 25°C.

Keep out of reach and sight of children.

To be supplied only on veterinary prescription.

For animal treatment only.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

LDPE tube with ethylene vinyl alcohol copolymer middle layer, HDPE top and polypropylene cap, containing 250 g of gel

Heparin inhibits blood coagulation. Owing to its strong anionic charge, it forms a complex with cationic protein bodies. This applies particularly to antithrombin III (AT III), a α2-globulin and endogenous inhibitor of the coagulation system, leading to a significant increase in its inhibitor reaction speed.

The essential action mechanism is the activation of AT III, which for its part inhibits thrombin and other serine proteases. Thus, not only thrombin (IIa), but also the activated factors XIIa, IXa, Xa and kallikrein are inactivated. This inactivation is dose-dependent.

Heparin also possesses a lipolysis-promoting action by activating the clearing factor and catalysing the release of lipoprotein lipase from endothelial cells, whereby large-molecular chylomicrons are solubilised in the plasma.

Heparin is involved in allergic and anaphylactic reactions. Heparin and histamine are released in the degranulation of mast cells. In haemostasis caused by shock, the presence of heparin reduces the coagulability of the blood. In addition, heparin acts as a mediator in the release of the histamine-degrading enzyme diamine oxidase.

Hydroxyethyl salicylate, an ester of salicylic acid, is very readily absorbed.

The salicylic acid released after absorption has an analgesic and anti-inflammatory effect. The action mechanism lies in the inhibition of prostaglandin synthesis and reduced formation of the pain-producing bradykinin from its precursors.

The released salicylic acid supports the antithrombotic effect of heparin by means of inhibition of platelet aggregation.

The keratolytic properties of salicylic acid further loosen the epidermis and facilitate absorption of the other active substances.

Levomenthol dissolved in alcohol has an antipruritic effect when applied to the skin and a mild local anaesthetic effect on the sensitive nerve endings of the skin.

At the same time it stimulates the cold receptors in the epidermis, whereby a cooling effect is felt, which is increased by the evaporation of the alcohol on the skin surface.

Heparin: Antithrombotic

Hydroxyethyl salicylate:Anti-inflammatory, analgesic; keratolytic

Levomenthol:Local anaesthetic, antipruritic

After absorption through the skin, heparin develops its complex effects in the superficial subcutaneous tissue. Penetration through healthy skin is dose-dependent and is proven for concentrations of 300 IU/g and above. After application to the skin, no systemically therapeutic concentrations are reached.

The salicylate is readily released from the hydrophilic gel base of Compagel and rapidly absorbed through the skin. In the tissue it is metabolised into salicylic acid and ethylene glycol. Part of the salicylate is degraded by oxidation and the rest is bound to glucuronic acid and excreted renally. Ethylene glycol is oxidised and excreted as oxalate.

Levomenthol is absorbed through the skin. It is metabolised in the liver by hydroxylation and subsequent glucuronidation.