Idiopathic Epilepsy
Oral administration at a dose range of 10 mg to 30 mg imepitoin per kg bodyweight twice daily, approximately 12 hours apart. Each tablet can be halved for appropriate dosing according to the individual bodyweight of the dog. Any remaining half-tablet should be used for the next dose.
The required dose will vary between dogs and will depend on the severity of the disorder. The recommended initial dose of imepitoin is 10 mg per kg bodyweight twice daily.
Initiate therapy using the bodyweight in kg and the dosing table. If seizures are not adequately reduced following a minimum of 1 week of treatment at the current dose the supervising veterinary surgeon should re-assess the dog. Assuming that the veterinary medicinal product is well tolerated by the dog, the dose can be increased by 50 to 100% increments up to a maximum dosage of 30 mg per kg administered twice daily.
Bioavailability is greater when administered to fasted dogs. The timing of tablet administration in relation to feeding should be kept consistent.
Number of tablets (to be given twice daily) for initiation of epilepsy treatment:
| Number of tablets |
Bodyweight (kg) | 100 mg | 400 mg |
5.0 | ½ | |
5.1 -10.0 | 1 | |
10.1 -15.0 | 1 ½ | |
15.1 - 20.0 | | ½ |
20.1 - 40.0 | | 1 |
40.1 - 60.0 | | 1 ½ |
Over 60 | | 2 |
Noise phobia
Oral administration at a dose of 30 mg imepitoin per kg bodyweight twice daily, approximately 12 hours apart. Each tablet can be halved for appropriate dosing according to the individual bodyweight of the dog.
Initiate therapy 2 days prior to the day of the expected noise event and continue through the noise event using the bodyweight in kg and the dosing table below.
Bioavailability is greater when administered to fasted dogs. The timing of tablet administration in relation to feeding should be kept consistent.
Number of tablets (to be given twice daily) for noise phobia treatment:
| Number of tablets |
Bodyweight (kg) | 100 mg | 400 mg |
2.5 - 3.9 | ½ | |
4 - 5.9 | 1½ | |
6 - 7.9 | 2 | |
8 - 10.9 | 3 | |
11 - 15.9 | | 1 |
16 - 22.9 | | 1½ |
23 - 29.9 | | 2 |
30 -36.9 | | 2½ |
37 - 43.9 | | 3 |
44 - 49.9 | | 3½ |
50 - 55.9 | | 4 |
56 - 71.9 | | 4½ |
72 -80 | | 5 |