Pharmacodynamic properties
Romifidine exerts sedative and analgesic effects. Its sedative effect is induced by stimulation of alpha-2-adrenoreceptors in the central nervous system. The substance possesses a strong specific affinity for these receptors.
Pharmacokinetic properties
Absorption: Since Sedivet is recommended to be administered intravenously, its active ingredient is completely bioavailable.
Distribution: Approximately 20% of romifidine is bound to plasma proteins. The highest drug concentrations are to be found in the liver and kidney.
Metabolism: Romifidine is found predominantly in kidney and muscle, whereas liver contains only traces of the parent compound. The major metabolites present in urine and tissues are SHT 2130, STH 2337 and ESR 1235, which have been shown to be pharmacologically inactive.
Elimination: Romifidine is rapidly eliminated: approximately 80% of the administered dose is via urine and the remainder via faeces.