Contraindications
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
Cattle (for environmental reasons):
Do not use in calves weighing more than 80 kg bodyweight.
Do not use in fattening units such as veal or beef calves.
Adverse effects
None known.
Overdose
A threefold overdose is well tolerated without adverse clinical signs.
Interaction with other medicinal products
None known. There is no interaction in combination with iron supplementation. Not to be mixed with other medicinal products.
Special warnings for each target species
As with any antiparasiticide, frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.
It is recommended to treat all piglets in a litter and all calves in a pen.
Hygienic measures may reduce the risk of porcine and bovine coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.
To alter the course of an established clinical coccidial infection in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.
To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.
Special precautions to be taken by the person administering the medicinal product to animals
Wash any splashes from skin or eyes immediately with water.
Wash hands after product administration.
People with known hypersensitivity to any of the ingredients should avoid contact with the veterinary medicinal product.
Other precautions
The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life > 1 year) and mobile in soil and to be toxic to plants.
In order to prevent any adverse effects on plants and possible contamination of groundwater, manure from treated calves must not be spread onto land without dilution with manure from toltrazuril untreated cattle. Manure from treated calves must be diluted with at least 3 times the weight of manure from toltrazuril untreated cattle before it can be spread onto land.
Withdrawal periods
Meat and offal:
Pigs (piglets) 77 days.
Cattle (calves) 63 days.
Not authorised for use in animals producing milk for human consumption.