For single administration only by subcutaneous injection. Each ml contains 10 mg of ivermectin sufficient to treat 50 kg of bodyweight of cattle and sheep, and 33 kg of bodyweight of pigs. Replace with a fresh sterile needle after every 10 to 12 animals. Massage the injection site after administration of the product. Injection of wet or dirty animals is not recommended.
Underdosing could result in ineffective use and may favour resistance development.
To ensure administration of a correct dose, body weight should be determined as accurately as possible. Accuracy of the dosing device should be checked.
If animals are to be treated collectively, reasonably homogeneous groups should be set up, and all animals of a group should be dosed at the rate corresponding to the heaviest one.
Cattle
The product should be given only by subcutaneous injection at the recommended dosage level of 200 microgram ivermectin per kg bodyweight under the loose skin in front of, or behind, the shoulder in cattle. This is equivalent to 1 ml per 50 kg bodyweight. The volume administered per injection site should not exceed 10 ml.
Pigs
In pigs, the recommended dosage level is 300 microgram ivermectin per kg bodyweight. This is equivalent to 1 ml per 33 kg bodyweight. The recommended route of administration is by subcutaneous injection into the neck.The volume administered per injection site should not exceed 5ml.
Young Pigs
In young pigs, especially those below 16 kg for which less than 0.5 ml of the product is indicated, dosing accurately is important. The use of a syringe that can accurately deliver as little as 0.1 ml is recommended.
Sheep
The recommended dose is 200 µg ivermectin per kg bodyweight (corresponding to 1 ml of the product per 50 kg bw) by subcutaneous injection over the neck.
The volume administered per injection site should not exceed 1ml.
For the treatment and control of sheep scab (Psoroptes ovis), two injections with a seven-day interval are required to treat clinical signs of scab and to eliminate mites.
In young lambs weighing less than 25 kg give 0.1 ml of the product per 5 kg. The use of a syringe that can deliver as little as 0.1 ml is recommended.
This product does not contain any antimicrobial preservative. Swab septum before removing each dose.
When using the 250 or 500ml pack sizes, use only automatic syringe equipment. For the 50ml pack size, use of a multiple dose syringe is recommended. To refill the syringe, use of a draw-off needle is recommended to avoid excessive broaching of the stopper
Overdose (symptoms, emergency procedures, antidotes), if necessary
In the case of overdose a symptomatic treatment should be given.
Cattle
Single doses of 4.0 mg ivermectin per kg (20 x the use level) given subcutaneously resulted in ataxia and depression.
Pigs
A dose of 30 mg ivermectin per kg (100 x the recommended dose of 0.3 mg per kg) injected subcutaneously to pigs caused lethargy, ataxia, bilateral mydriasis, intermittent tremors, laboured breathing and lateral recumbency.
Sheep
At dose levels up to 4 mg ivermectin per kg (20 x the use level) given subcutaneously resulted in ataxia and depression.
No antidote has been identified; however, symptomatic therapy may be beneficial.