Do not administer by the intra-carotid route.
Careful consideration should be given before administering to animals exposed to stress conditions such as extreme heat, cold, high altitude or fatigue.
Following use of Chanazine 2% in cattle profuse salivation, bloat and polyuria may occur. Tympany should be avoided in recumbent cattle by maintaining the animal in sternal recumbency. Provision should also be made for facilitating dependent drainage from the mouth to avoid inhalation asphyxia.
Side Effects such as bradycardia, cardiac arrhythmia and polyuria may occur in the horse. Following intravenous administration to horses, a transient rise followed by a fall in blood pressure usually occurs.
Profound cardiovascular effects or exacerbated side effects specified above may result from overdosage. Cattle are 10 times more sensitive than horses. Do not repeat the dose in the event of unsatisfactory response. Repeat on the following day with recalculated dosage.
Vomiting is commonly observed in dogs and cats following use of the preparation.
Chanazine 2% should not be administered in the later stages of pregnancy because of the risk of inducing premature parturition. As the safety of xylazine use during organogenesis has not been fully demonstrated by current methods it should be used with caution during the first month of pregnancy.
Not to be used where pulmonary disease or gastro-intestinal obstruction are suspected.
Withdrawal Period
Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 14 days from the last treatment. Not for use in animals from which milk is produced for human consumption. Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.
Operator warnings
Xylazine is an alpha adrenoceptor agonist acting primarily on alpha-2 receptors. Precautions should be taken to avoid accidental injection /self injection.
Horses sedated with Xylazine usually remain standing and may still kick with accuracy.
1. In the case of accidental oral intake or self-injection, seek medical advice immediately and show the package leaflet to the doctor but DO NOT DRIVE as sedation and changes in blood pressure may occur.
2. Avoid skin, eye or mucosal contact.
3. Immediately after exposure, wash the exposed skin with large amounts of fresh water.
4. Remove contaminated clothes that are in direct contact with skin.
5. In the case of accidental contact of the product with eyes, rinse with large amounts of fresh water. If symptoms occur, seek the advice of a doctor.
6. If pregnant women handle the product, special caution should be observed not to self inject as uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure.
7. Advice to Doctors: Xylazine is an alpha2-adrenoreceptor agonist. Symptoms after absorption may involve clinical effects including dose-dependent sedation, respiratory depression, brachycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.
Environmental warnings
Dispose of any unused product or containers in accordance with guidance from your local waste regulation authority.
General precautions
For animal treatment only. Keep out of the reach of children.