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Pharmacological particulars
Pharmacotherapeutic group: Ophthalmologicals containing antibiotics.
ATCvet code: QS01AA13
Pharmacodynamic properties
Fusidic acid, the active substance of the veterinary medicinal product, is active against Staphylococcus aureus and in particular against the biotype Staphylococcus intermedius which is a common isolate from clinical cases of canine conjunctivitis.
In the cat, ocular bacterial infection is usually secondary to viral, Chlamydia or Mycoplasmal infection or trauma. Among the variety of bacteria found, the Staphylococcus spp. are considered to be sensitive to fusidic acid.
In the rabbit, ocular infections are associated with a variety of organisms which are sensitive to fusidic acid, the most common of which are Staphylococci.
Pharmacokinetic properties
The sustained release formulation of the veterinary medicinal product ensures prolonged retention within the conjunctival sac. Once or twice daily applications will provide inhibitory levels of fusidic acid against the sensitive organisms.
Studies have shown that fusidic acid penetrates well into the cornea and anterior chamber in humans and rabbits.